Motor neuron target selectivity and survival after prolonged axotomy
نویسندگان
چکیده
منابع مشابه
Survival motor neuron: motor neuron insurance for a whole lifespan?
The SMN (survival motor neuron) gene plays an important role in ontogenesis and its dysfunction leads to immatu-rity of skeletal muscles and motor neurons in the spinal cord. As a result of SMN mutations the affected cells die and clinical symptoms of spinal muscular atrophy (SMA) develop. Physiologically, SMN together with gemins is part of a multiprotein complex of particular importance to mo...
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Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spinal motor neurons. Low levels of SMN also occur in models of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1) and genetic reduction of SMN levels exacerbates the phenotype of transgenic SOD1(G93A) mice. Here, we demonstrate that SMN protein is significantly reduc...
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To determine whether changes in androgen receptor (AR) expression are associated with trophic actions of androgens, we have examined the laryngeal motor nucleus (N. IX-X) of Xenopus laevis 1 and 5 months after section of the laryngeal nerve. In situ hybridization was used to recognize cells expressing mRNA for the Xenopus AR and bromodeoxyuridine to assess cell proliferation. In addition, the t...
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Spinal muscular atrophy (SMA) is attributed to mutations in the SMN1 gene, leading to loss of spinal cord motor neurons. The neurotropic Sindbis virus vector system was used to investigate a role for the survival motor neuron (SMN) protein in regulating neuronal apoptosis. Here we show that SMN protects primary neurons and differentiated neuron-like stem cells, but not cultured cell lines from ...
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ژورنال
عنوان ژورنال: Restorative Neurology and Neuroscience
سال: 2013
ISSN: 0922-6028
DOI: 10.3233/rnn-120301